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东北红豆杉(TaxuscuspidataSibeetZucc)枝叶乙醇提取物的二氯甲烷溶部分显示有较强的抗肿瘤活性,从这部分中已分离出十二个紫杉烷类二萜化合物,经理化常数测定和光谱解析证明其中十个为已知化合物taxinine(I),taxinineA(II),taxinineB(III),taxacin(V),taxagifine(VI),taxol(VII),cephalomannine(VIII),taxinineM(IX),10-deacetylbaccatinIII(X)和taxayuntin(XI),另二个化合物为新成分,分别命名为10-deacetyltaxinineB(IV)和taxacustin(XII),其中化合物VII,VIII,IX,X和XI均为首次从该植物枝叶中分离得到。
The methylene chloride fraction of ethanol extract of Taxuscus pidata Sibeet Zucc showed strong antitumor activity. Twelve taxane diterpene compounds have been isolated from this part, and the determination of the managerial constants and spectral analysis Proof that ten of them are known compounds taxinine(I), taxinineA(II), taxinineB(III), taxacin(V), taxagifine(VI), taxol(VII), cephalomannine(VIII), taxinineM(IX), 10- deacetylbaccatinIII (X) and taxayuntin (XI), the other two compounds are new components, named 10-deacetyltaxinine B (IV) and taxacustin (XII), respectively, wherein compound VII, VIII, IX, X XI are isolated from the leaves of the plant.