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目的探讨慢性肾脏病(CKD)患者反勺型血压与肾功能损害的相关性。方法选择2011年1月至2014年9月收治的277例CKD患者为研究对象,使用携带式动态血压计监测动态血压,收集血压及相关临床指标等资料,评价反勺型血压与肾功能损害的相关性。结果 CKD患者反勺型血压占23.39%,非勺型血压46.95%,勺型血压27.15%。与勺型及非勺型血压患者相比,肾小球滤过率显著下降(P<0.05)。多因素回归分析结果显示,反勺型血压是CKD患者肾小球滤过率下降的独立危险因素。结论反勺型血压是中国CKD患者常见的血压模式之一,反勺型血压患者肾功能损害更显著。
Objective To investigate the correlation between the inverse blood pressure and renal dysfunction in patients with chronic kidney disease (CKD). Methods A total of 277 patients with CKD admitted from January 2011 to September 2014 were enrolled in this study. Ambulatory blood pressure, blood pressure and related clinical data were monitored by portable ambulatory sphygmomanometer to evaluate the relationship between anti-systolic blood pressure and renal dysfunction Correlation. Results The CKD patients had 23.39% of backfat blood pressure, 46.95% of non-dipper blood pressure and 27.15% of spoonful blood pressure. Glomerular filtration rate (P <0.05) was significantly lower than that of spoon-type and non-spoon-type blood pressure patients. Multivariate regression analysis showed that backspin blood pressure was an independent risk factor for glomerular filtration rate (GFR) decline in CKD patients. Conclusions Back-spike blood pressure is one of the most common blood pressure patterns in Chinese patients with CKD. Renal dysfunction is more significant in patients with back-spike blood pressure.