论文部分内容阅读
胃排空受许多因素的影响,许多疾病可以引起胃动力障碍,药物也可以导致胃排空的异常,胃排空异常又会影响某些药物的药动学和药效学,现就药物与胃排空问题简述如下:一、药物对胃排空的影响1、心血管系统用药:钾盐口服液,影响胃肠蠕动、延缓胃排空,其机理未明。静注多巴胺可延缓空腹胃排空。左旋多巴在胃被多巴脱羧酶作用放出多巴胺,作用于胃平滑肌细胞中的多巴胺受体而延缓混合性食物的排空。利血平耗竭交感神经递质,使副
Gastric emptying is affected by many factors, many diseases can cause gastric motility disorders, drugs can also cause abnormal gastric emptying, abnormal gastric emptying can affect the pharmacokinetics and pharmacodynamics of certain drugs, and now on the drug and Gastric emptying problems are summarized as follows: First, the impact of drugs on gastric emptying 1, the cardiovascular system medication: Potassium oral liquid, affecting gastrointestinal motility, delayed gastric emptying, the mechanism is unknown. Intravenous dopamine can delay fasting gastric emptying. Levodopa releases dopamine in the stomach by dopa decarboxylase, which delays the emptying of mixed foods by acting on dopamine receptors in gastric smooth muscle cells. Reserpine depletes the sympathetic neurotransmitter, making the deputy