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目的了解佛山市三水区新生儿乙肝疫苗免疫无应答的影响因素,为乙肝疫苗免疫无应答人群提供一定的参考和建议。方法对辖区幼儿园4岁年龄组(限在±半岁年龄)共608名儿童采取检测乙肝标记物,查阅免疫接种资料及电话询问等方式,筛查出符合条件的病例组,并按1:2配对方法抽查对照组。采用Logistic回归分析,计算各因素与乙肝疫苗免疫无应答关系的比值比(OR)及其95%可信区间(95%CI)。结果多因素Logistic回归分析,父亲乙肝病毒HBsAg阳性相对于父亲各项感染指标全阴时,婴儿出现免疫无应答的OR=1.645(95%CI 1.1120～2.4340),父亲乙肝病毒HBsAb阳性相对于父亲各项感染指标全阴,婴儿出现免疫无应答的OR=0.7070(95%CI 0.5180～0.9630),父亲有乙肝疫苗免疫无应答史,婴儿出现免疫无应答的OR=1.49(95%CI 1.108～2.005),第三次接种疫苗剂量,OR=2.574(95%CI1.110～5.964),婴儿用餐具消毒效果OR=1.2510(95%CI 1.009～1.5520)经以上统计分析,差异有统计学意义。结论 “父亲乙肝病毒HBsAg阳性”、“父亲有乙肝疫苗免疫无应答史”、“第三次接种疫苗剂量”、婴儿用餐具消毒效果为新生儿乙肝免疫无应答的危险因素,而“父亲HBsAb阳性”是新生儿乙肝免疫无应答的保护因素。
Objective To understand the influencing factors of non-response to hepatitis B vaccine in newborns in Sanshui District of Foshan City, and to provide some references and recommendations for non-responders to hepatitis B vaccine. Methods A total of 608 children in the 4-year-old kindergarten (± 0.5 years of age) in the district were enrolled in this study. A total of 608 children were tested for hepatitis B markers, immunization information and telephone inquiries. Paired method checks the control group. Logistic regression analysis was used to calculate the odds ratio (OR) and its 95% confidence interval (95% CI) for the relationship between each factor and the unresponsiveness to hepatitis B vaccine. Results Multivariate Logistic regression analysis showed that infant immunosuppressed with no HBsAg-positive relative to all the indicators of her pregnancy had OR = 1.645 (95% CI 1.1120-2.440), and the positive rate of HBsAg-positive hepatitis B virus The index of infection was all negative, OR = 0.7070 (95% CI 0.5180 ~ 0.9630) in infants with no immune response, father had no history of immune response to hepatitis B vaccine, OR = 1.49 (95% CI 1.108-2.005) , The third dose of vaccination, OR = 2.574 (95% CI1.110 ~ 5.964), baby tableware disinfection effect OR = 1.2510 (95% CI 1.009 ~ 1.5520) The above statistical analysis, the difference was statistically significant. Conclusion “The father of hepatitis B virus HBsAg positive”, “father has hepatitis B vaccine non-response history”, “The third vaccination dose”, baby tableware disinfection effect of neonatal hepatitis B immune non-response risk factors , While “father’s HBsAb positive” is the protective factor of neonatal hepatitis B immune non-response.