局灶性节段性肾小球硬化(FSGS)是由多种原因引起的一种较常见的肾组织病理改变,在小儿肾脏疾病中发病率也较高,据文献报道小儿肾病综合征中FSGS占4—10％。由于FSGS与许多原发性肾脏疾病自然缓解后或治疗控制后肾功能进行性恶化有关,近年来已渐引起重视。关于肾脏疾病发生FSGS并呈现慢性经过的原因,目前多认为与肾小球的高滤过等因素有关,并在发病机理、 Focal segmental glomerulosclerosis (FSGS) is caused by a variety of reasons a more common pathological changes in renal tissue, the incidence of renal disease in children is also higher, according to the literature reported in children with nephrotic syndrome FSGS Accounting for 4-10%. Since FSGS has been associated with the progressive deterioration of renal function after natural remission or after treatment control in many primary kidney diseases, it has drawn increasing attention in recent years. On the occurrence of renal disease FSGS and chronic exacerbation of the reasons, at present think more and glomerular hyperfiltration and other factors, and in the pathogenesis,