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目的测定早产儿脐带血可溶性白细胞分化抗原14(sCD14)水平,探讨其与自发性早产新生儿危重程度评分的相关性。方法孕28～36+5周分娩的自发性早产儿69例、非自发性早产儿27例和健康足月儿12例入选本研究。利用ELISA测定其脐带血sCD14水平。对患儿进行新生儿危重程度评分。结果与非自发性早产儿及健康足月儿比较,自发性早产儿脐带血sCD14水平明显升高,差异具有统计学意义(Pa=0.009,0.006);早产儿脐带血sCD14水平与新生儿危重程度评分呈正相关(r=0.806,P=0.002)。结论 sCD14水平升高参与自发性早产的过程,sCD14水平升高可能与新生儿危重程度相关。
Objective To determine the cord blood soluble leukocyte differentiation antigen 14 (sCD14) level in preterm infants and explore the relationship between sCD14 levels and the criticality scores of neonates with spontaneous preterm birth. Methods 69 cases of spontaneous preterm labor, 27 cases of non-spontaneous preterm birth and 12 healthy term children were enrolled in this study. Umbilical cord blood sCD14 levels were measured by ELISA. Neonatal children were scored on the severity of the illness. Results Compared with non-spontaneous preterm infants and healthy term infants, the cord blood sCD14 levels in spontaneous preterm infants were significantly increased (Pa = 0.009,0.006). The cord blood sCD14 level in preterm infants was significantly higher than that in neonates The scores were positively correlated (r = 0.806, P = 0.002). Conclusion The increased sCD14 level is involved in spontaneous preterm labor. Elevated levels of sCD14 may be related to the severity of newborn infants.