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目的:研究固本益气滋阴汤对2型糖尿病胰岛β细胞保护功能。方法:选取糖尿病气阴两虚证患者300例,随机数字法分为治疗组和对照组,其中治疗组151例;对照组149例。两组患者均在接受糖尿病饮食和常规运动,对照组给予马来酸罗格列酮片口服每天1次,每次1片,治疗组在对照组治疗方案的基础上,给予固本益气滋阴汤每日1剂水煎服,早晚分两次服用。两组均以连续服药8周为1个疗程。比较治疗前后两组症候积分,糖化血红蛋白指数,空腹及餐后2 h血糖和胰岛素水平,以及胰岛β细胞功能评价相关指数胰岛素作用指数(IAI),胰岛素抵抗指数(IR)和HOMA-β指数。结果:两组中医症候积分均比治疗前显著降低(P<0.05),但治疗组中医症候积分下降程度比对照组明显(P<0.05);对照组和治疗组患者空腹和餐后2 h血糖以及糖化血红蛋白指数与治疗前相比均显著降低(P<0.05),对照组和治疗组患者餐后2 h血胰岛素含量与治疗前相比均显著升高(P<0.05),但两组治疗后各时点上述指标相比无显著差异(P>0.05);两组患者治疗后胰岛作用指数IAI和Homa-β指数显著升高(P<0.05),治疗组比对照组升高更显著(P<0.05);两组Homa-IR指数均比治疗前显著下降(P<0.05),治疗组该指数显著低于对照组(P<0.05)。结论:固本益气滋阴汤对2型糖尿病胰岛β细胞有保护功能。
Objective: To study the protective effect of Guben Yiqi Ziyin decoction on islet β-cell in type 2 diabetic patients. Methods: 300 cases of diabetic Qi-Yin Deficiency Syndrome were selected and randomly divided into treatment group and control group, 151 cases in the treatment group and 149 cases in the control group. Both groups were undergoing diabetic diet and regular exercise. The control group was given rosiglitazone maleate tablets orally once daily, one tablet each time. On the basis of the treatment regimen of the control group, the treatment group was given Guben Qiqi Yin Decoction 1 day daily decoction, taking twice daily morning and evening. Both groups took continuous treatment for 8 weeks as a course of treatment. Symptom scores, glycosylated hemoglobin index (HbA1c), fasting and postprandial 2h blood glucose and insulin levels, and insulin-like activity index (IAI), insulin resistance index (HOMA-β) index were compared between the two groups before and after treatment. Results: The TCM symptom scores of both groups were significantly lower than those before treatment (P <0.05), but the TCM symptom scores of the two groups were significantly lower than those of the control group (P <0.05). The fasting and postprandial blood glucose (P <0.05). The plasma insulin levels of 2 h after meal in control group and treatment group were significantly higher than those before treatment (P <0.05), but both groups were significantly lower than those before treatment There was no significant difference between the above indexes at each time point (P> 0.05). IAI and Homa-β index of the two groups were significantly increased after treatment (P <0.05), and the treatment group was more significant than the control group P <0.05). The Homa-IR index of both groups decreased significantly (P <0.05), and the index of the treatment group was significantly lower than that of the control group (P <0.05). Conclusion: Guben Yiqi Ziyin Decoction has protective function on type 2 diabetes islet β cells.