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[目的]探讨人工膝关节置换(TKA)术后早期应用局部超声药物透入辅助镇痛和功能锻炼的效果.[方法]选取2016年6月至2017年5月于本院行单侧TKA患者41例,随机分为观察组21例和对照组 20例.两组患者分别给予相同基础镇痛方案,从术后2周起观察组患者辅助局部超声透入药物(利多卡因+倍他米松),4周共10次.随访两组患者至术后3个月,分别记录术前活动度,AKS评分,术后2周,6周,3个月时平均活动度,视觉模拟评分(VAS)和AKS评分.[结果]①两组患者术前的活动度,AKS评分及术后2周的活动度,运动后VAS评分比较差异无统计学意义(P >0.05);②术后6周观察组的活动度为(110.0± 12.3)°,VAS为(2.0±1.0)分,对照组为(102.3± 10.4)°,VAS为(2.9±1.3)分,两组比较差异有统计学意义(P<0.05);③术后3个月,观察组的活动度为(116.4± 10.7)°,AKS功能评分为(84.0±10.6)分,对照组活动度为(111.0±10.9)°,AKS功能评分为(76.0士 12.4)分,观察组优于对照组,差异有统计学差异(P 0.05);② At 6 weeks after operation,the activity of the observation group was (110.0±12.3)°,the VAS score was (2.0±1.0) points, the control group was (102.3± 10.4)°,the VAS score was (2.9 ± 1.3) points,the difference between the two groups was statistically significant (P <0.05).③ Three months after operation, the activity of the observation group was (116.4±10.7)°, the score of AKS function was (84.0±10.6),the activity of the control group was (111.0±10.9)°,the score of AKS function was (76.0土 12.4). The observation group was superior to the control group(P <0.05).[Con- clusionlUltrasound phonophoresis therapy with lidocaine and betamethasone can effectively relieve postoperative pain after TKA and is helpful to functional rehabilitation of patients with obvious early pain after TKA.