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目的采用Meta分析评价Ghrelin基因SNP+408C/A位点多态性与T2DM的相关性。方法检索中国知网、维普、万方、Pubmed、Cochrone library、OVID数据库,收集2000年1月至2012年5月公开发表的有关Ghrelin基因SNP+408C/A位点多态性与T2DM相关性研究的文献;按一定标准对文献质量进行综合评价,提取有效数据,采用Review Manager 5.1软件进行Meta分析。结果共纳入研究8篇,累计病例3944例,对照3967例。Meta分析结果显示,Ghrelin基因+408C/A位点多态性与T2DM的相关性中C等位基因与A等位基因(OR:1.02,95%CI:0.93～1.12,P=0.61)、基因型CC与(CA+AA)(OR:0.99,95%CI:0.89～1.10,P=0.80)、基因型CC与CA(OR:0.98,95%CI:0.88～1.10,P=0.73)、基因型CC与AA(OR:1.2,95%CI:0.90～1.60,P=0.22)比较,差异均无统计学意义。结论 Ghrelin基因+408C/A位点多态性与T2DM易感性可能无关。
Objective To evaluate the association between SNP + 408C / A polymorphism in Ghrelin gene and T2DM by Meta-analysis. METHODS: The data of SNP + 408C / A polymorphism in Ghrelin gene and T2DM published from January 2000 to May 2012 were collected from Chinese Knowledge Network, VIP, Wanfang, Pubmed, Cochrone library and OVID database. ; According to a certain standard, the comprehensive evaluation of the quality of the literature, extraction of valid data, the use of Review Manager 5.1 software for meta-analysis. Results A total of 8 studies were included, with a total of 3944 cases and 3967 controls. Meta analysis showed that there was no significant difference between C allele and A allele (OR: 1.02, 95% CI: 0.93-1.12, P = 0.61) in the correlation between + 408C / A polymorphism and T2DM in Ghrelin gene, (OR: 0.99, 95% CI: 0.89-1.10, P = 0.80), genotype CC and CA (OR: 0.98,95% CI: 0.88-1.10, P = 0.73) Type CC and AA (OR: 1.2, 95% CI: 0.90-1.60, P = 0.22), the difference was not statistically significant. Conclusion The polymorphism of Ghrelin + 408C / A locus may not be related to the susceptibility to T2DM.