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采用放射免疫分析法检测了尿蛋白定性检查呈阴性反应的慢性乙型肝炎、活动性肝硬变59例患者尿微量白蛋白(UALb)、尿免疫球蛋白G(UIgG)、尿β_2-微球蛋白(Uβ_2m)和尿Tamm-Horsfall蛋白(THP)。109名健康人为对照组。结果:59例患者中17例UALb排泄量显著增加,与对照组比较,差异有显著性(P<0.001);其中5例UIgG排泄量增加。UALb排泄量增加的17例患者中,16例Uβ_2m排泄量增加,9例THP排泄量减少,与对照组比较,均有显著性意义(P<0.001)。检测结果表明:乙型肝炎病毒持续感染可造成患者肾脏损伤,可同时累及肾小球及肾小管。检测UALb、UIgG,Uβ_2m和THP有助于发现肾脏早期损伤及损伤部位。
Radioimmunoassay was used to detect urinary protein qualitative negative reaction of chronic hepatitis B, active cirrhosis in 59 patients with urinary albumin (UALb), urinary immunoglobulin G (UIgG), urinary β_2-microspheres Protein (Uβ_2m) and urine Tamm-Horsfall protein (THP). 109 healthy people as control group. Results: The excretion of UALb in 17 of 59 patients increased significantly compared with that in control group (P <0.001). The excretion of UIgG in 5 patients increased. Among the 17 patients with increased UALb excretion, 16 cases of Uβ_2m excretion increased and 9 cases of THP excretion decreased compared with the control group (P <0.001). Test results show that: hepatitis B virus infection can cause kidney damage in patients with glomerular and renal tubules can be involved. Detection of UALb, UIgG, Uβ_2m and THP can help detect early kidney injury and injury sites.