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为观察奥美拉唑对颅脑手术病人胃内ｐＨ的影响，研究其对颅脑手术后上消化道出血的预防作用。作者将２０例颅脑手术病人随机分为两组，对照组１０ 例，术后予以常规治疗，奥美拉唑组１０ 例，术后除常规治疗外予以奥美拉唑４０ｍ ｇ 每日１ 次静脉推注。所有病人术前４ｈ 开始胃内７２ｈ ｐＨ监测，并记录有无呕血、黑便、输血及大便隐血试验阳性。发现颅脑手术病人术中胃内ｐＨ 明显升高（Ｐ＜ ０．０１），但术后胃内ｐＨ 显著下降（Ｐ＜０．０５）。奥美拉唑可阻断术后胃内ｐＨ下降，使术后胃内ｐＨ 高于术前（Ｐ＜ ０．０１），与对照组比，奥美拉唑组术后胃内ｐＨ明显升高（Ｐ＜ ０．０１）。术后对照组病人呕血２ 例、黑便１ 例、大便隐血阳性２ 例；奥美拉唑组仅１例出现大便隐血阳性。提示颅脑手术病人存在术后胃酸高分泌；奥美拉唑可抑制术后胃酸分泌，对上消化道出血有预防作用
To observe the influence of omeprazole on intragastric pH in patients undergoing craniocerebral surgery and study its preventive effect on upper gastrointestinal bleeding after craniocerebral surgery. Twenty patients with craniocerebral surgery were randomly divided into two groups, the control group of 10 patients, after conventional treatment, 10 cases of omeprazole group, after treatment in addition to conventional treatment of omeprazole 40m g once daily Intravenous injection. All patients began to monitor the stomach 72h pH 4h before operation, and recorded whether hematemesis, melena, blood transfusion and fecal occult blood test was positive. It was found that intraoperative gastric pH was significantly increased in patients undergoing craniocerebral surgery (P <0.01), but gastric pH was significantly decreased after operation (P <0.05). Omeprazole could block the decrease of intragastric pH and postoperative intragastric pH was higher than preoperative (P <0.01). Compared with the control group, omeprazole group postoperative gastric pH was significantly increased (P <0.01). The patients in the control group had hematemesis in 2 cases, melena in 1 case and fecal occult blood in 2 cases. In only 1 case of omeprazole group, fecal occult blood was positive. Prompt brain surgery in patients with postoperative gastric acid secretion; omeprazole can inhibit gastric acid secretion, the prevention of upper gastrointestinal bleeding