对６８例肺癌组织进行纤维连接蛋白（Ｆｎ）免疫组织化学研究。癌周基膜Ｆｎ在肺腺癌随着分化的不成熟而表达减少或消失。在肺腺癌与鳞癌中表达方式不全相同。间质中Ｆｎ的表达与肿瘤的组织学分型及分化无关，而与新生的纤维结缔组织及血管密切相关，提示与肿瘤的运动、浸润及诱生血管提供肿瘤生长有关。 The fibronectin (Fn) immunohistochemical study was performed on 68 lung cancer tissues. Pericardial basement membrane Fn expression decreases or disappears as lung adenocarcinoma develops with immature differentiation. In lung adenocarcinoma and squamous cell carcinoma, the expression pattern is not the same. The expression of Fn in the interstitium has nothing to do with the histological type and differentiation of the tumor, but is closely related to the neonatal fibrous connective tissue and blood vessels, suggesting that it is related to the tumor’s movement, infiltration, and induction of blood vessels to provide tumor growth.