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目的 探讨核素99mTc -HL91乏氧显像对肺癌诊断和治疗的临床价值。方法 72例原发性肺癌患者行SPECT99m Tc -HL91显像 ,根据早期 ( 1h)显像和延迟 ( 3h)显像结果进行定性和半定量分析。并对其中接受化疗的 65例患者按延迟显像T/N值分组进行疗效随访。结果 99mTc -HL91早期和延迟显像对肺癌诊断的灵敏度分别为 86 1%( 62 / 72 )、98 6%( 71/ 72 )。不同病理类型的肺癌半定量分析结果比较差异无显著性。 65例化疗患者低摄取组疗效较高摄取组好 ,差异有显著性 (P <0 0 5 )。结论 99mTc -HL91乏氧显像对原发性肺癌的诊断具有较高的灵敏度 ,并在预测治疗效果方面具有一定的应用价值
Objective To investigate the clinical value of radionuclide 99mTc -HL91 hypoxia imaging in the diagnosis and treatment of lung cancer. Methods Seventy-two patients with primary lung cancer underwent SPECT99m Tc-HL91 imaging. Qualitative and semi-quantitative analysis was based on early (1h) imaging and delayed (3h) imaging. Sixty-five patients undergoing chemotherapy were followed up according to the delayed imaging T / N value. Results The sensitivity of 99m Tc -HL91 early and delayed imaging in diagnosing lung cancer were 86.1% (62/72) and 98 6% (71/72), respectively. Semi-quantitative analysis of lung cancer with different pathological types showed no significant difference. In the 65 patients with low-dose chemotherapy group, the effect of high-intake group was better, the difference was significant (P <0 05). Conclusion 99mTc-HL91 hypoxia imaging has high sensitivity for the diagnosis of primary lung cancer and has certain value in predicting the therapeutic effect