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溃疡性结肠炎(UC)是一种有结肠直肠癌发展倾向的疾病。结肠炎侵犯脾曲附近和有7～10年临床病史的患者被称为高危人群。在UC患者中,发育异常常出现在癌症之前,这种症状已被认为是判断病人有结肠直肠癌高危象的标志。多数作者认为UC患者行内镜和活组织检查有利于防止致命性的结肠癌进一步发展。 本文研究的主要目的是估计UC患者发育异常或癌变的进展,并且判定随访中结肠镜和活组织检查在结肠癌的监督中的有效性。 从1980～1986年,65例患UC长达7年或7年以上的病人参与到结肠镜和活组织检查的监测。这组病人随访持续到1992年10月。49例患者(75.4％)有广泛性结肠炎,16例(24.6％)有左侧结肠炎。疾病持续时间平均为17.2年。共完成了304次结肠镜检
Ulcerative colitis (UC) is a disease that has a tendency to develop colorectal cancer. Patients with colitis invading the spleen and having a clinical history of 7 to 10 years are known as high-risk groups. In patients with UC, dysplasia often precedes cancer. This symptom has been considered to be a sign of a high risk of colorectal cancer. Most authors believe that endoscopic and biopsy of UC patients can help prevent the further development of fatal colon cancer. The main purpose of this study was to estimate the developmental abnormalities or the progression of canceration in UC patients and to determine the effectiveness of colonoscopy and biopsy in the surveillance of colon cancer at follow-up. From 1980 to 1986, 65 patients with UC up to 7 years or more participated in the monitoring of colonoscopy and biopsy. Follow-up of this group of patients continued until October 1992. Forty-nine patients (75.4%) had extensive colitis and 16 (24.6%) had left colitis. The average duration of the disease was 17.2 years. A total of 304 colonoscopy tests were performed