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目的研究T2DM患者血清胰岛素样生长因子结合蛋白7(IGFBP7)与IR的相关性。方法选取新诊断T2DM患者(T2DM组)137例和健康体检者(NC组)96名,测定两组FPG、FIns、血脂、C-RP、肿瘤坏死因子α(TNF-α)和IGFBP7。结果 T2DM组除TC和LDL-C外,其余指标与NC组比较差异有统计学意义(P<0.05)。按T2DM组IGFBP7四分位数将其分成4组(Q1～4),各组间年龄、BMI、C-RP、TNF-α、FIns、HOMA-IR和HOMA-IS差异有统计学意义(P<0.05);新诊断T2DM患者IG-FBP7与年龄、BMI、C-RP、TNF-α、FIns和HOMA-IR呈正相关(r=0.264、0.173、0.255、0.227、0.192、0.325,P<0.05),与HOMA-IS呈负相关(r=-0.324,P<0.01)。年龄、C-RP、TNF-α和HOMA-IR是影响新诊断T2DM患者IGFBP7水平的独立因素(β′=0.318、0.186、0.239、0.255,P<0.05)。结论新诊断T2DM患者IGFBP7与年龄、C-RP、TNF-α和HOMA-IR密切相关。
Objective To investigate the correlation between serum insulin-like growth factor binding protein 7 (IGFBP7) and IR in T2DM patients. Methods Totally 137 newly diagnosed T2DM patients (T2DM group) and 96 healthy volunteers (NC group) were selected. The levels of FPG, FIns, lipids, C-RP, TNF- α and IGFBP7 were measured in two groups. Results In T2DM group, except for TC and LDL-C, the other indexes had statistical significance compared with NC group (P <0.05). The differences of age, BMI, C-RP, TNF-α, FIns, HOMA-IR and HOMA-IS between the groups were statistically significant according to the quartiles of IGFBP7 in T2DM group (P < <0.05). IG-FBP7 was positively correlated with age, BMI, TNF-α, FIns and HOMA-IR in newly diagnosed T2DM patients (r = 0.264,0.173,0.255,0.227,0.192,0.325, P <0.05) , But negatively correlated with HOMA-IS (r = -0.324, P <0.01). Age, C-RP, TNF-α and HOMA-IR were independent factors affecting the level of IGFBP7 in newly diagnosed T2DM patients (β ’= 0.318,0.186,0.239,0.255, P <0.05). Conclusion IGFBP7 in newly diagnosed T2DM patients is closely related to age, C-RP, TNF-α and HOMA-IR.