A single nucleotide polymorphism (SNP) is the most frequent type of variation in the genome.There are around 10 million SNPs that have been identified in the human genome [1].Because SNPs are highly conserved throughout evolution and within a population,the map of SNPs serves as an excellent genotypic marker for research.The elucidation of SNP information will contribute to an individuals susceptibility to disease and responsiveness to drug toxicity and medical intervention [2,3].Nowadays,a variety of techniques have been used to perform SNP genotyping,but these techniques required whole blood as the sample.Dried blood spot (DBS) specimens require less material and are substantially more stable (several months at room temperature) than whole blood [4].Thus,the simplicity of sample preparation,long time storage and convenient transport make DBS to be a cost-effective and suitable altemative tool for collecting blood sample.