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目的:探讨肾上腺髓质素(Adrenomedullin,ADM)对缺血再灌注后肾功能的保护作用。方法:在注射外源性ADM蛋白后,建立急性缺血再灌注肾损伤模型,观察ADM对肾功能和氧化损伤指标肌酐(Creatinine,Cr)、尿素氮(Blood Urea Nitrogen,BUN)、髓过氧化物酶(Myeloperoxidase,MPO)、丙二醛(Malondialdehyde,MDA)、超氧化物歧化酶(Superoxide Dismutase,SOD)影响。结果:与I组比较,II组的Cr、BUN、MPO、MDA大幅升高(P<0.05),表明急性肾损伤造模成功。与II相比,III组BUN、MPO、MDA明显下降(P<0.05),表现出一定的保护作用。结论:ADM对缺血再灌注损伤后的肾功能具有一定的保护作用,其机制可能与减少中性粒细胞浸润,抑制膜脂质的氧化,促进微血管重生修复有关。
Objective: To investigate the protective effect of adrenomedullin (ADM) on renal function after ischemia-reperfusion. Methods: Acute ischemia-reperfusion injury model was established after administration of exogenous ADM protein. The effects of ADM on renal function and creatinine (Cr), blood urea nitrogen (BUN), myeloperoxidase Myeloperoxidase (MPO), malondialdehyde (MDA) and superoxide dismutase (SOD). Results: Compared with group I, the levels of Cr, BUN, MPO and MDA in group II increased significantly (P <0.05), which indicated that the model of acute kidney injury was successfully established. Compared with II, BUN, MPO and MDA in group III were significantly decreased (P <0.05), showing some protective effect. CONCLUSION: ADM has a protective effect on renal function after ischemia-reperfusion injury, and its mechanism may be related to reducing neutrophil infiltration, inhibiting membrane lipid oxidation and promoting microvascular regeneration.