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目的调查温州市瓯海区居民高尿酸血症(HUA)和代谢综合征(MS)的患病情况,分析血尿酸水平(SUA)与MS的关系,为HUA的预防提供依据。方法采用多阶段整群随机抽样方法,选取温州市瓯海区3 905名18岁及以上居民为研究对象,调查HUA和MS患病情况及MS各组分检出率;应用多因素非条件Logistic回归分析HUA与MS各组分的相关性。结果瓯海区居民HUA患病率为17.77%,标化率为16.73%;MS患病率为23.46%,标化率为17.16%。男性HUA患病率为20.26%,高于女性15.65%(P<0.01)。女性HUA患病率随年龄增长呈上升趋势(P<0.01)。总MS患病率及男、女MS患病率均随年龄增长而增加(P<0.01)。Logistic回归分析显示,腰围(OR=1.025,95%CI:1.014~1.035)、TG水平(OR=1.361,95%CI:1.265~1.464)及年龄(OR=1.008,95%CI:1.002~1.015)与HUA呈正相关(P均<0.05);其中男性腰围(OR=1.024,95%CI:1.009~1.038)、TG水平(OR=1.262,95%CI:1.129~1.411)及年龄(OR=1.014,95%CI:1.004~1.025)与HUA呈正相关(P均<0.01);女性腰围(OR=1.022,95%CI:1.006~1.038)及TG水平(OR=1.429,95%CI:1.295~1.578)与HUA呈正相关(P<0.01)。结论瓯海区居民HUA患病率存在年龄、性别差异,SUA与MS、腰围及TG水平呈正相关。
Objective To investigate the prevalence of hyperuricemia (HUA) and metabolic syndrome (MS) among residents in Ouhai District of Wenzhou City. The relationship between serum uric acid level (SUA) and MS was analyzed to provide evidence for the prevention of HUA. Methods A multistage cluster random sampling method was used to select 3 905 residents aged 18 years and older in Ouhai District of Wenzhou City as subjects. The prevalence of HUA and MS and the detection rate of MS were investigated. Multivariate non-conditional logistic regression Regression analysis of the correlation between HUA and MS components. Results The prevalence of HUA in Ouhai district was 17.77%, the standardization rate was 16.73%. The prevalence of MS was 23.46% and the standardization rate was 17.16%. The prevalence of HUA was 20.26% in males, 15.65% higher than females (P <0.01). The prevalence of HUA in women increased with age (P <0.01). The prevalence of MS and the prevalence of MS in both men and women increased with age (P <0.01). Logistic regression analysis showed that there was significant difference between the two groups (OR = 1.025, 95% CI: 1.014-1.035), TG level (OR = 1.361, 95% CI: 1.265-1.464) and age (OR = 1.008, 95% CI: 1.002-1.015) (OR = 1.024, 95% CI: 1.009-1.038), TG level (OR = 1.262, 95% CI: 1.129-1.411) and age (OR = 1.014, (OR = 1.022, 95% CI: 1.006-1.038) and TG levels (OR = 1.429, 95% CI: 1.295-1.578) were significantly correlated with HUA (P <0.01, 95% CI: 1.004-1.025) And HUA was positively correlated (P <0.01). Conclusion The prevalence of HUA among residents in Ouhai district is age and sex difference. There is a positive correlation between SUA and MS, waist circumference and TG level.