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目的观察乳腺癌组织与乳腺癌淋巴结转移中血管内皮生长因子C(VEGF-C)和血管内皮生长因子受体3(VEGFR-3)的表达的相关性,探讨其在乳腺癌组织与淋巴结转移中的表达及意义。方法采用免疫组化法检测76例乳腺癌组织及转移淋巴结中VEGF-C及VEGFR-3的表达情况,计算其阳性表达率。结果乳腺癌组织中VEGF-C、VEGFR-3的表达水平与淋巴结转移显著相关(P<0.01),而VEGF-C、VEGFR-3的表达与患者的年龄、癌的分化程度等无关(P>0.05)。结论 VEGF-C可能通过与VEGFR-3的结合刺激了淋巴结的增生、扩张,并通过提高淋巴管的渗透性,从而对癌的淋巴结转移起促进作用。
Objective To observe the correlation between the expression of vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor receptor 3 (VEGFR-3) in breast cancer tissues and lymph node metastasis, The expression and significance. Methods Immunohistochemistry was used to detect the expression of VEGF-C and VEGFR-3 in 76 cases of breast cancer and metastatic lymph nodes, and the positive rate of VEGF-C and VEGFR-3 was calculated. Results The expressions of VEGF-C and VEGFR-3 in breast cancer tissues were significantly correlated with lymph node metastasis (P <0.01), while the expressions of VEGF-C and VEGFR-3 had no correlation with the age, 0.05). Conclusion VEGF-C may stimulate the proliferation and expansion of lymph nodes through the combination with VEGFR-3, and promote the lymph node metastasis by increasing the lymphatic permeability.