基因组印迹是指基因由于亲代来源不同的表达。与印迹基因相关的两个关键时期包括配子形成期和植入前胚胎期。在这两个时期发生的任何异常都会导致印迹基因功能缺陷并由此导致疾病的产生。而目前已被应用于临床治疗不孕不育的人类辅助生殖技术中的一些操作都有可能影响到这两个关键过程,从而导致一些与印迹有关疾病发生率增高,人类辅助生殖技术和人类基因组印迹缺陷可能存在某种关系,需要对人类辅助生殖技术的安全性做进一步评估。 Genomic imprinting refers to the expression of a gene due to its parental origin. Two key stages associated with imprinted genes include the gametophyte formation period and the preimplantation embryo stage. Any abnormality that occurs during these two periods can lead to impaired gene function of the imprinted gene and consequent disease development. However, some of the current human assisted reproductive technologies that have been used clinically to treat infertility may affect both of these key processes, resulting in increased rates of some imprinted diseases, human assisted reproductive technologies and the human genome There may be a relationship between imprinting defects and the need for further evaluation of the safety of human assisted reproductive technologies.