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目的:观察保济丸粉辐照前后对小鼠的腹泻及肠运动的影响。方法:采用蓖麻油致小鼠腹泻模型,观察辐射前后保济丸粉的止泻作用;采用溴吡斯的明致小鼠肠运动亢进模型观察对炭末推进的影响,观察对小鼠不同肠段水分吸收的影响。以上实验辐照前后保济丸粉剂量均为给生药1.3,2.6,5.2 g.kg-1,ig,连续3 d。结果:保济丸粉辐照前后可显著延长蓖麻油致小鼠腹泻的起始时间(开始排湿粪时间),显著减少腹泻次数(排泄湿粪次数),与模型对照组比较,P<0.01;可显著抑制溴吡斯的明所致小鼠小肠运动亢进作用,与模型对照组比较,P<0.01或P<0.05;可显著减少小鼠大肠与小肠水分含量,与正常对照组比较,P<0.01或P<0.05。结论:保济丸粉辐照前后均可止泻和抑制肠运动,其止泻作用可能是通过抑制肠运动及减少小鼠肠腔内水分所致。保济丸粉辐照前后的作用比较,差异无显著性。
Objective: To observe the effects of Baoyu pill powder on diarrhea and intestinal motility in mice before and after radiation. Methods: Diarrhea model induced by castor oil in mice was used to observe the anti-diarrhea effect of Baoji Pill before and after irradiation. The effects of bromopyrazine on mouse model of intestinal hyperactivity were observed, Section of the impact of water absorption. Before and after the above experimental irradiation, the doses of Baogu pills were 1.3, 2.6, 5.2 g.kg-1, ig for crude drugs for 3 consecutive days. Results: Before and after Baoyu pill irradiation, the onset time of diarrhea induced by castor oil in mice was significantly prolonged (the time of starting wetting feces) and the frequency of diarrhea was significantly decreased (P <0.01 compared with the model control group) ; Compared with the model control group, P <0.01 or P <0.05; It can significantly reduce the water content in the large intestine and the small intestine of mice, Compared with the normal control group, P <0.01 or P <0.05. Conclusion: Baoyi pill powder can both inhibit diarrhea and inhibit bowel movement before and after irradiation. The antidiarrheal effect may be caused by inhibiting bowel movement and decreasing the intestinal lumen moisture in mice. Baoji pills before and after irradiation the role of comparison, the difference was not significant.