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目的:评估0、1、2号片、复方左炔诺孕酮单相片和复方左炔诺孕酮三相避孕片的安全性。方法:见“我国常用口服避孕药和宫内节育器系统评估的方法概述”(中国计划生育学杂志,2005年1期17页)。结果:共检索到83篇相关文献,入选20篇。与服药前相比,国产1、2号片和复方左炔诺孕酮单相片对妇女脂代谢的某些指标有影响。与IUD相比,1号片可升高妇女的舒张压。上述脂代谢和血压的改变均无临床意义。0、1号片可能增加心血管意外的风险,但这些影响都较小。结论:国产1、2号片和复方左炔诺孕酮单相片对使用者的脂代谢和血压改变有影响,0、1号片可能增加脑血管意外风险,考虑到心血管意外在年轻健康妇女(≤35岁)中发病率很低,且被评估的短效口服药的雌激素剂量≤35μg/片,故认为被评估的短效口服避孕药对年轻健康使用者心血管疾病的绝对风险很小。
OBJECTIVE: To evaluate the safety of three-phase contraceptive tablets, 0,1,2 tablets, levonorgestrel single-phase and levonorgestrel. Methods: See “China’s commonly used methods of oral contraceptives and IUD assessment system” (Chinese Journal of family planning, 2005 1 period 17 pages). Results: A total of 83 related articles were retrieved and 20 were selected. Compared with the pre-medication, domestic tablets No. 1 and levonorgestrel single-phase effects on some indicators of lipid metabolism in women. Compared with IUD, No. 1 tablets can increase women’s diastolic blood pressure. The lipid metabolism and blood pressure changes are not clinically significant. 0,1 tablets may increase the risk of cardiovascular accidents, but these effects are small. CONCLUSIONS: Domestic 1,2 and 3 levonorgestrel mono-tablets have effects on lipid metabolism and blood pressure changes in users. However, 0 and 1 tablets may increase the risk of cerebrovascular accidents. Taking into account the cardiovascular accidents in young and healthy women (≤35 years old), and the estimated short-acting oral dose of estrogen is ≤35 μg / tablet, the absolute risk of short-acting oral contraceptives being evaluated for cardiovascular disease in young and healthy users is very high small.