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目的掌握江西省接受抗病毒治疗的成年艾滋病患者的死亡现状及影响因素,提出适合的防艾措施,为提高江西省艾滋病抗病毒治疗工作的效果提供参考依据。方法对江西省所有2004-2012年接受抗病毒治疗的成年艾滋病患者的基本情况及治疗信息进行调查与随访。采用Logistic回归模型分析影响死亡的因素。结果 2 103例江西省艾滋病治疗患者中,男性为主占71.28%。年龄集中在30~49岁。已婚或同居者占61.01%。感染途径以性传播为主79.89%。临床Ⅰ~Ⅳ期的患者分别占35.76%、22.82%、21.73%、19.69%。前5位的机会性感染疾病分别为:持续或间断发热16.98%、肺结核7.85%、皮肤损害5.80%、持续腹泻5.56%、带状疮疹5.09%。CD4+细胞异常率为99.34%。多因素Logistic回归分析发现:年龄越大(OR=1.03)、临床分期越接近Ⅳ期(OR=1.44)、持续腹泻(OR=1.97)、持续或间断发热(OR=1.68)、患肺结核(OR=1.86)、患鹅口疮(OR=2.65)、患播散性真菌病(OR=4.68)、CD4+细胞个数越少(OR=0.99)、血源传播9个因素是江西省艾滋病成年治疗患者死亡的危险因素。结论江西省艾滋病治疗患者以男性青壮年,性活跃人群为主。应加强对当地的婚外性行为的控制和推广安全套使用。提倡早期发现、早期诊断与早期治疗,帮助AIDS患者早期发现机会性感染,教会正确处理各种常见疾病症状的方法,减轻不适症状带来的困扰,提高患者的生存率。
Objective To know the current status of death and the influencing factors of adult AIDS patients receiving antiviral therapy in Jiangxi Province and to put forward suitable anti-AIDS measures to provide reference for improving the effect of AIDS antiviral therapy in Jiangxi Province. Methods The basic information and treatment information of all AIDS patients receiving antiretroviral therapy from 2004 to 2012 in Jiangxi Province were investigated and followed up. Logistic regression model was used to analyze the factors affecting death. Results 2 103 cases of AIDS patients in Jiangxi Province, male accounted for 71.28%. Concentrated in the age of 30 to 49 years old. Married or cohabitants accounted for 61.01%. The main route of transmission is sexual transmission 79.89%. Patients in clinical stage Ⅰ-Ⅳ accounted for 35.76%, 22.82%, 21.73% and 19.69% respectively. The top 5 opportunistic infections were: persistent or intermittent fever 16.98%, tuberculosis 7.85%, skin damage 5.80%, persistent diarrhea 5.56% and band-shaped sores 5.09%. The abnormal rate of CD4 + cells was 99.34%. Multivariate Logistic regression analysis showed that the older the clinical stage was (OR = 1.03), the closer the clinical stage was to stage IV (OR = 1.44), persistent diarrhea (OR = 1.97), persistent or intermittent fever (OR = 2.65), disseminated mycosis (OR = 4.68), fewer CD4 + cells (OR = 0.99), and 9 factors of blood-borne transmission in AIDS-refractory adult patients in Jiangxi Province The risk of death. Conclusion The AIDS patients in Jiangxi Province are dominated by male young adults and sexually active people. It is necessary to strengthen the control over local extramarital sex and promote the use of condoms. Promote early detection, early diagnosis and early treatment to help AIDS patients early detection of opportunistic infections, the church correctly handle the symptoms of various common diseases, relieve the discomfort caused by symptoms and improve patient survival.