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乙型肝炎病毒(HBV)的传染与坏死后肝硬化和原发性肝癌(PHC)有关。在 PHC多的地区,乙型肝炎表面抗原(HBsAg)出现率也高。一些研究者提出:(1)由于传播方式和宿主反应的不同,使 HB 的传染集中在某些家庭中;(2)传播和宿主反应二者的特殊类型与 PHC 有关。如果真是如上所述,那末这些传播方式和宿主反应类型应就将是发生 PHC 的危险因素。本文根据小量样品的研究对上述假说、危险因素、以及这些因素对 PHC 的相对和绝对危险性进行了试验、监定和计算。作者对塞内加尔达卡的28个 PHC 病人和28个显然健康的邻居作对照研究。分析了病人、对照、病人的父母、对照者的父母以及病人的71个和对照者的58个兄弟姐妹的血清中 HBsAg(免疫扩散法及放射免疫分析法)、HBsAg 的抗体(Anti-
Hepatitis B virus (HBV) infection is associated with post-necrotic cirrhosis and primary liver cancer (PHC). In areas with high PHC, the incidence of hepatitis B surface antigen (HBsAg) is also high. Some researchers propose that (1) HB infection be concentrated in some households due to differences in modes of transmission and host response, and (2) the specific types of both transmission and host response are related to PHC. If so, as described above, these modes of transmission and host response should be the risk factors for developing PHC. Based on a small sample of studies, the above hypotheses, risk factors, and the relative and absolute risks of these factors to PHC were tested, monitored, and calculated. The authors compared 28 PHC patients with 28 apparently healthy neighbors in Dhaka, Senegal. HBsAg (immunodiffusion and radioimmunoassay), anti-HBsAg antibody (anti-HBsAg) in sera of patients, controls, patients ’parents, controls’ parents and patients and 71 siblings of 58 controls were analyzed.