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目的 考核乙型肝炎(乙肝)疫苗的免疫效果。方法 通过常规免疫接种率报告系统和法定传染病报告系统获取乙肝疫苗接种率和乙肝发病率,抽样调查≤14岁儿童乙肝疫苗接种率,同时采集血清标本用酶联免疫吸附试验(ELISA)法检测乙肝病毒表面抗原(HBsAg)、乙肝病毒表面抗体(抗 HBs)、乙肝病毒核心抗体(抗 HBc)。结果 1991～2 0 0 1年潍坊市≤14岁儿童乙肝疫苗接种率为0 . 2 8%～86. 6 8% ,乙肝发病率6 . 78/10万～1 85 /10万,乙肝发病率与乙肝疫苗接种率呈负相关,有非常显著的统计学意义(r =0 .9333,P <0 . 0 1)。抽样调查≤14岁儿童1178人,HBsAg、抗HBs、抗 HBc阳性率分别为1 .10 %、71. 14 %、8 .15 % ,未开展接种乙肝疫苗前的1993年抽样调查≤14岁儿童75 6人,HBsAg、抗 HBs、抗 HBc阳性率分别为3 17%、12 .. 98%、10 .0 5 % ,开展接种前后HBsAg、抗 HBs阳性率差异均有非常显著的统计学意义(χ2 =10 . 5 2、6 2 4 . 0 0 ,P均<0 . 0 1)。结论 乙肝疫苗有较好的免疫效果。
Objective To assess the immune effect of hepatitis B (hepatitis B) vaccine. Methods Hepatitis B vaccination rate and hepatitis B incidence rate were obtained through routine vaccination rate reporting system and legal notifiable disease reporting system. The hepatitis B vaccination rate of children ≤14 years old was sampled by sampling and the serum samples were collected by enzyme-linked immunosorbent assay (ELISA) Hepatitis B virus surface antigen (HBsAg), Hepatitis B virus surface antibody (anti-HBs), Hepatitis B virus core antibody (anti-HBc). Results In 1991 ~ 2001, the vaccination rate of hepatitis B in children ≤14 in Weifang was 0.28% ~ 86.68%, the incidence rate of hepatitis B was 6.778-1.85%, the incidence of hepatitis B And hepatitis B vaccination rate was negatively correlated, there is a very significant statistically significant (r = 0. 9333, P <0.01). A sample survey of 1178 children ≤14 years of age, HBsAg, anti-HBs, anti-HBc positive rates were 1.10%, 71.14%, 8.15%, before the introduction of hepatitis B vaccine 1993 sampling survey ≤14 years of age children The positive rates of HBsAg, anti-HBs and anti-HBc were 75%, 75%, 75% respectively. The positive rates of HBsAg and anti-HBs before and after vaccination were all significantly different χ2 = 10. 5 2,6 2 4. 0 0, P <0. 0 1). Conclusion Hepatitis B vaccine has a better immune effect.