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血管内皮生长因子(VEGF)是一种重要的血管生成刺激因子,是特异作用于血管内皮细胞、上调血管生成的重要因子,能刺激血管内皮细胞增殖、迁移和诱导血管生成,其家族中VEGF-C、VEGF-D和VEGFR-3在乳腺癌淋巴道转移中起重要作用,可以作为乳腺癌患者的独立预后判断因素。以VEGF为靶点的抗血管化治疗成为治疗乳腺癌的新方法,通过对VEGF信号通路的抑制是目前抗癌治疗研究热点之一。
Vascular endothelial growth factor (VEGF) is an important angiogenic stimulating factor that is an important factor that acts on vascular endothelial cells and up-regulates angiogenesis. It can stimulate the proliferation, migration and angiogenesis of vascular endothelial cells. VEGF- C, VEGF-D and VEGFR-3 plays an important role in lymphatic metastasis of breast cancer and can be used as an independent prognostic factor in patients with breast cancer. Anti-angiogenic therapy targeting VEGF has become a new method for the treatment of breast cancer. Inhibition of VEGF signaling pathway is one of the hot topics in anti-cancer therapy.