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目的:探讨急性脑梗死患者血浆纤维蛋白原(F g)水平在不同时间段的变化及低分子肝素治疗对其影响.方法:选择2012年1月至2015年1月收治的脑梗死患者100例,随机分为抗凝组和非抗凝组各50例,并设立健康对照组50例.抗凝组在常规治疗基础上加用低分子肝素钙抗凝治疗,分别于治疗第1天和第10天检测血浆Fg水平,并在治疗前后进行神经功能缺损评分比较.结果:急性脑梗死组第1天和第10天血浆F g水平明显高于对照组(P<0.01);抗凝组与非抗凝组治疗前后F g水平比较,治疗前两组无差异,治疗后,抗凝组较非抗凝组明显降低,两组比较,差异有统计学意义(P<0.01);应用低分子肝素干预治疗10天后,抗凝组神经功能缺损评分优于非抗凝组,两组差异有统计学意义(P<0.05).结论:急性脑梗死后血浆F g水平明显增高,应用低分子肝素抗凝治疗能降低患者血凝状态,提高临床疗效.“,”Objective Acute cerebral infarction in patients with plasma fibrinogen function(Fg) measured at different time changes and the impact of treatment with low molecular weight heparin.Methods We selected 100 cases of cerebral infarction were randomly divided into the anticoagulant group and the control group 50 cases,and the establishment of a healthy group 50,in conventional anticoagulation therapy based on the use of low molecular weight heparin heparin anticoagulant therapy, respectively, in the first day 10 Fg level detection, and neurological deficit scores before and after treatment.Results Cerebral infarction group at all time points of plasma Fg levels were significantly higher than the control group (P<0.01);Compare anticoagulation group and control group before and after treatment Fg level,no difference before treatment,after treatment,the anticoagulant group was significantly lower,compare the two groups was significant difference(P<0.01);low molecular weight heparin for 10 days after the intervention,anticoagulation neurological deficit scores than the control group, the difference was statistically significant (P<0.05).Conclusion Patients with acute cerebral infarction, plasma Fg levels were significantly increased,low molecular weight heparin anticoagulant therapy can reduce blood clotting status of patients,and can improve the therapeutic effect.