影响肾移植远期疗效的主要原因是慢性排斥反应,但也有不少受者于肾移植后1年或数年肾功能在短期内发生严重损害(临床诊断为急性排斥反应),这些受者一部分对激素冲击治疗反应良好,但另一部分则冲击治疗无效,移植肾损害逐渐加重,且肾功能大多数在1年内丧失[1],其原因尚不清楚。1 Long-term effects of renal transplantation is the main reason for chronic rejection, but there are also many recipients of kidney function in a few years after renal transplantation or severe damage in a short period of time (clinical diagnosis of acute rejection), part of these recipients The response to hormone shock treatment is good, but the other part of the impact of treatment is invalid, graft damage gradually increased, and most of the renal function was lost within 1 year, the reason is not clear. 1