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研究中国动脉粥样硬化性脑梗死（ACI）患者和正常人载脂蛋白B（apoB）基因XbaI和EcoRI两位点多态性与血脂水平的关系。方法采用聚合酶链式反应技术检测了85例ACI患者及56例正常人（NC）的apoB基因多态性。结果（1）NC组X-X+基因型血浆TC水平明显高于X－X－基因型（P＜0．001）；ACI组与NC组少见E＋E－或E－E－基因型，血浆TG水平明显高于E＋E＋基因型（P＜0．02）。（2）X－X－基因型个体：ACI组血浆TC、TG、apoB、Lp（a）水平明显高于NC组，apoA水平明显低于NC组。（3）ACI组EcoRI位点不同基因型个体TC、TG水平均明显高于NC组，而apoA水平明显低于NC组。结论呈X－X－基因型患者可能与ACI患者血脂异常有关，apoB基因多态性对血浆TC、TG水平影响较大。
To study the relationship between polymorphisms of XbaI and EcoRI apolipoprotein B (apoB) gene and serum lipids in Chinese patients with atherosclerotic cerebral infarction (ACI) and normal subjects. Methods Polymerase chain reaction (PCR) was used to detect apoB gene polymorphism in 85 patients with ACI and 56 normal controls (NC). Results (1) The level of plasma TC in X-X + genotype of NC group was significantly higher than that of X-X genotype (P <0.001). The genotypes of E + E- or E-E- Significantly higher than the E + E + genotype (P <0.02). (2) The level of TC, TG, apoB and Lp (a) in X-X- genotypes: ACI group was significantly higher than that in NC group, apoA level was significantly lower than NC group. (3) The levels of TC and TG in different genotypes of EcoRI in ACI group were significantly higher than those in NC group, while the levels of apoA in ACI group were significantly lower than those in NC group. Conclusion The patients with X-X- genotype may be associated with dyslipidemia in ACI patients. The polymorphism of apoB gene has a significant effect on plasma TC and TG levels.