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目的:观察地尔硫革(Dil)减少肾移植受者他克莫司(Tac)用量、改善肾功能的效能。方法:肾移植术后3周,将Dil 用于36例服用Tac的肾移植受者,以同期30例受者为对照,观察两组用药后1年内Tac用量和肾功能变化。结果:用Dil后 1周,该组Tac血浓度平均升高56％,术后12月内,每例Tac用量平均较对照组少380 mg,两组Tac血浓度无显著差异(P> 0．05);12月时,Dil组血肌酐明显低于对照组(126．1±36．3 vs．145．8±41．5μmol·L-1,P<0．05)。结论:Dil可明显减少肾移植受者的Tac用量,对移植肾功能亦具有保护作用。
Objective: To observe the efficacy of diltiazem (Dil) in reducing the amount of Tac in renal transplant recipients and improving renal function. Methods: Three weeks after renal transplantation, Dil was used in 36 renal transplant recipients who received Tac. Control was given to 30 recipients in the same period. Changes in Tac dosage and renal function were observed within one year after treatment. Results: After 1 week of Dil, the Tac blood concentration in this group increased 56% on average. Within 12 months after operation, the average amount of Tac used in each case was 380 mg less than that of the control group. There was no significant difference between the two groups in Tac blood concentration (P> 0.05). 05). In December, serum creatinine in Dil group was significantly lower than that in control group (126.1 ± 36.3 vs.145.8 ± 41.5μmol·L-1, P <0.05). Conclusion: Dil can significantly reduce the amount of Tac in renal transplant recipients and also have protective effects on renal graft function.