以卡马西平、丙戊酸等为代表的传统抗癫痫药物(AEDs)由于价格低廉,效果稳定而仍广泛应于临床,但其能通过多种机制对骨髓造血功能造成全面的抑制,并可形成血小板自身抗体以及对血小板的直接毒性作用,从而导致再生障碍性贫血、出血以及急性髓样白血病样反应等一系列不良反应。而以托吡酯、奥卡西平、拉莫三嗪等为代表的新型AEDs血液系统毒性较小,罕有严重血液系统不良反应的发生,临床应用安全性高。 Traditional antiepileptic drugs (AEDs), such as carbamazepine and valproic acid, are still widely used clinically due to their low price and stable effect, but they can completely inhibit the hematopoietic function of bone marrow through various mechanisms. The formation of platelet autoantibodies and the direct toxicity of platelets, resulting in a series of adverse reactions such as aplastic anemia, hemorrhage and acute myeloid leukemia-like reactions. The newer AEDs, represented by topiramate, oxcarbazepine and lamotrigine, have less toxicity and rare serious adverse reactions of the blood system, and have high safety in clinical application.