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Russell.等发现小量1.25-双羟基胆钙化醇(1,25-(OH)_2-D_3)及1α-羟基胆钙化醇(1α-OH-D_3)能迅速纠正甲状旁腺功能低减病人的低钙血症。作者报告1例(11岁,女)有类似的治疗效果。患者每日口服0.001毫克的1,25-(OH)_2-D_310天,血清钙从6.6毫克％升至9.4毫克％。患者摄取医院中的一般饮食,未另服钙剂。1,25-(OH)_2-D_3的作用缓慢减弱,于4周后患者有轻度的低钙症状(血清钙8.1毫克％)。此时给予原用量的1/4即0.00025毫克1,25-(OH)_2-D_3治疗,低血钙未见改善,但未再进一步减低。又给予病人每日0.001毫克的剂量使血钙恢复正常后,改用每日0.00025毫克,但此剂量太少,不能维持正常血钙水平。看来,每日0.001毫克可能是在甲状旁腺功能低减病人达到并维持正常血钙水平的最低治疗量。另一例9岁患假性甲状旁腺功能低减的女孩,其
Russell et al found that a small amount of 1,2-dihydroxycholecalciferol (1,25- (OH) 2-D_3) and 1α-hydroxycholecalciferol (1α-OH-D_3) can quickly correct the patients with hypoparathyroidism Hypocalcemia. The authors reported a similar treatment effect in 1 patient (11 years old, female). Patients were orally given 0.001 mg of 1,25- (OH) _2-D_310 daily and serum calcium increased from 6.6 mg% to 9.4 mg%. The patient ingests the general diet in the hospital without further serving of calcium. The effect of 1,25- (OH) _2-D_3 was slowly attenuated, with mild hypocalcemia (serum calcium 8.1 mg%) after 4 weeks. At this time to give the original amount of 1/4 or 0.00025 mg 1,25 - (OH) _2-D_3 treatment, no improvement in hypocalcemia, but did not further reduce. Give the patient a daily dose of 0.001 mg so that blood calcium returned to normal 0.00025 mg per day, but this dose is too small, can not maintain normal blood calcium levels. It appears that 0.001 mg daily may be the lowest amount of treatment in patients with hypoparathyroidism to achieve and maintain normal blood calcium levels. Another case of 9-year-old girl with hypoparathyroidism, its