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目的:探讨脑脊液细胞学检查中出现中性粒细胞的早期诊断价值。方法:收集我院脑脊液细胞学检查1203例,采用细胞玻片自然沉淀室,瑞氏-姬姆萨染色(MGG),光学显微镜分类计数。结果:脑脊液细胞学发现中性粒细胞共210例,占全部CSF细胞学检查的17.46%,包括感染性疾病和非感染性疾病。其中,感染性疾病中病毒性脑炎30例、结核性脑炎72例、隐球菌性脑炎14例、化脓性脑炎54例;非感染性疾病中系统性红斑狼疮性脑炎30例、神经白塞病4例、脑膜癌6例。中性粒细胞在脑脊液细胞的比例:病毒性脑炎占60%~80%,结核性脑炎占40%~80%,隐球菌性脑炎占0%~30%,化脓性脑炎占70%~90%,系统性红斑狼疮性脑炎5%~70%,神经白塞病占40%,脑膜癌占0%~20%。结论脑脊液细胞学出现中性粒细胞对中枢神经系统感染性疾病早期诊断有重要的价值。
Objective: To investigate the early diagnosis of neutrophils in cerebrospinal fluid cytology. Methods: A total of 1203 cases of cerebrospinal fluid cytological examination in our hospital were collected and classified by microscope using Wright’s microscope, Wright-Giemsa staining (MGG) and cell microscope. Results: Cerebrospinal fluid cytology found that a total of 210 cases of neutrophils, accounting for 17.46% of all CSF cytology tests, including infectious diseases and non-infectious diseases. Among them, 30 cases of viral encephalitis in infectious diseases, tuberculous encephalitis in 72 cases, cryptococcal encephalitis in 14 cases, purulent encephalitis in 54 cases; non-infectious diseases in systemic lupus erythematosus encephalitis in 30 cases, 4 cases of neurological Behcet’s disease, 6 cases of meningeal cancer. The proportion of neutrophils in cerebrospinal fluid cells: viral encephalitis 60% to 80%, tuberculous encephalitis 40% to 80%, cryptococcal encephalitis 0% to 30%, purulent encephalitis accounted for 70% % ~ 90%, systemic lupus erythematosus encephalitis 5% ~ 70%, neuro Behcet’s disease 40%, meningeal cancer 0% ~ 20%. Conclusion Neutrophils in cerebrospinal fluid cytology have important value in the early diagnosis of central nervous system infectious diseases.