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观察腹腔内持续热灌注（ＣＨＰＰ）对胃肠道手术病人呼吸力学、血液动力学及其他生化指标的影响。方法 ＡＳＡⅠ～Ⅱ级择期胃肠道肿瘤手术病人１７ 例，吻合口缝合完毕后进行ＣＨＰＰ。整个手术和热化疗过程中呼吸力学、血液动力学及生化代谢监测。结果 体温：ＣＨＰＰ后血温和颅脑温增高非常明显。ＣＨＰＰ过程中由于颈部局部降温，血温和颅肺温增高相差程度也非常显著（Ｐ＜ ００１）。呼吸：ＣＨＰＰ过程中增高，Ｃｏｍ ｐｌ降低（Ｐ＜ ００１），ＣＨＰＰ结束后恢复正常。ＰＥＴ ＣＯ２ 在ＣＨＰＰ３０ 分钟后开始显著增加。循环：ＣＨＰＰ后ＣＩ由（３３±０９）Ｌ·ｍ ｉｎ－ １ 增高至（４６３±０８）Ｌ·ｍ ｉｎ－ １ ，并维持到手术结束。ＨＲ显著增快，至ＣＨＰＰ结束后又显著下降。ＣＨＰＰ过程中ＭＡＰ显著下降，ＣＨＰＰ结束后恢复到热灌注前水平。ＳＶＲＩ由（１９０３±４４８）降至（１２４６±２５２）ｄｙｎ·ｓ·ｃｍ － ５ ·ｍ － ２（Ｐ＜ ００５），ＳＶＩ无显著变化。ＭＰＡＰ、ＰＡＷＰ、ＣＶＰ均较ＣＨＰＰ前显著增高（Ｐ＜ ００１），ＣＨＰＰ结束即恢复正常。生化代谢：ＣＨＰＰ后ＤＯ２Ｉ、ＶＯ２Ｉ显著增高，ｐＨ、ＢＥ、Ｈｂ 则显著下降（Ｐ＜ ０?
To observe the effects of intraperitoneal continuous thermal infusion (CHPP) on respiratory mechanics, hemodynamics, and other biochemical indicators in patients undergoing gastrointestinal surgery. Methods Seventeen ASAI-II patients undergoing elective gastrointestinal tumor surgery were performed with CHPP after anastomoses were sutured. Respiratory mechanics, hemodynamics, and biochemical metabolic monitoring throughout surgery and thermochemotherapy. Results Body temperature: The increase of blood temperature and cranial temperature after CHPP was very obvious. During the CHPP process, the temperature difference between the blood temperature and the cranial lung temperature was also significantly different due to local cooling of the neck (P<001). Respiratory: During the CHPP increase, the Com pl decreased (P < 0 01), and the CHPP returned to normal after the end. PET CO2 began to increase significantly after 30 minutes of CHPP. Circulation: After CHPP, CI increased from (33±09)L·m in−1 to (463±08)L·m in−1 and maintained until the end of the operation. HR increased significantly, and dropped significantly after the end of CHPP. MAP significantly decreased during CHPP and returned to pre-Heat perfusion after the end of CHPP. SVRI decreased from (1903±448) to (1246±252) dyn·s·cm -5 ·m - 2 (P<005), and there was no significant change in SVI. MPAP, PAWP, and CVP were all significantly higher than before CHPP (P < 0 01). The end of CHPP returned to normal. Biochemical metabolism: DO2I and VO2I increased significantly after CHPP, while pH, BE, and Hb decreased significantly (P<0).