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临床上,静脉注射利多卡因可抑制心室的应激性,且副作用较少。然而治疗剂量的利多卡因可以短暂地但明显地降低心肌的功能。本文探讨治疗剂量利多卡因作静脉一次注射或静脉滴注时对左心室功能的影响。方法:13条狗,于静脉注射利多卡因的前后,在改良的右心转流制备下测定其左心室功能。第1组5条狗系静脉一次注入,第2组8条狗则为静脉滴注(1毫克/公斤/小时,滴注1小时)。两组动物均作右心转流,隔除肺循环,左心房用氧化动脉血灌注。心排出量用流量刻度泵控制在600～2300毫升/分的不同水平,平均动脉压维持在90毫米汞柱。钳碎窦房结,用心房起搏法使心率控制在100次/分。平均动脉压、左心房压、左心室舒张末期压,心电图及左心室dp/dt用多导
Clinically, intravenous lidocaine can inhibit ventricular stress, and fewer side effects. However, a therapeutic dose of lidocaine transiently but significantly reduced myocardial function. This article investigates the effects of lidocaine at a therapeutic dose on left ventricular function in a single intravenous injection or intravenous infusion. Methods: Thirteen dogs were tested for left ventricular function before and after intravenous injection of lidocaine under modified right heart bypass. The first group of five dogs intravenous injection, the second group of eight dogs intravenous infusion (1 mg / kg / h, drip for 1 hour). Two groups of animals were for right heart bypass, isolated pulmonary circulation, left atrial oxidation with arterial blood perfusion. Cardiac discharge volume control with a flow rate of 600 ~ 2300 ml / min at different levels, the average arterial pressure maintained at 90 mm Hg. Nip the sinus node, heart rate pacing method with atrial pacing control at 100 beats / min. Mean arterial pressure, left atrial pressure, left ventricular end-diastolic pressure, electrocardiogram, and left ventricular dp / dt were measured with multi-detector