“七五”和“八五”计划期间 ,我国对第一代乙型肝炎 (乙肝 )疫苗 (血源疫苗 )的新生儿免疫效果进行了近期和远期效果考核 ,均证明效果良好。“九五”期间又对第二代乙肝疫苗(基因工程疫苗 )效果进行考核 ,以最后取代血源疫苗。本文报道对我国研制的在哺乳动物细胞中高效表达的 During the “Seventh Five-Year Plan” and the “Eighth Five-Year Plan”, our country conducted the short-term and long-term effects assessment on the neonatal immunization effects of the first-generation hepatitis B vaccine (blood-borne vaccine), all of which proved effective. During the Ninth Five-year Plan period, the second generation hepatitis B vaccine (genetically engineered vaccine) was evaluated again to finally replace the blood-borne vaccine. This article reports on the development of our highly expressed in mammalian cells