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一、成人T 细胞白血病(ATL)ATL 首先由高月清等人于1977年提出,并描述了其临床特征。特别是最先注意到病集中在日本的四国南部和九州,使人们想到了非洲Burkitt 淋巴病的地区分布,并高度怀疑此病存在着某种类似EB 病毒的致病因子。二、成人T 细胞白血病病毒(ATLV)的发现1979年三好等应用人脐带血的白细胞与ATL 患者的末梢血混合培养,从而确立了来自ATL 的细胞株MT-1。1981年日沼等发现,以MT-1与ATL 患者的血清反应后,再与标有荧光素的抗人IgG 反应,有一定的细胞产生荧光,这种抗原称为(ATL)相关抗原,电
First, adult T-cell leukemia (ATL) ATL was first proposed by Gao Yueqing et al in 1977, and described its clinical features. In particular, the first to note that the disease is concentrated in southern Japan and Kyushu in Japan reminds people of the geographical distribution of Burkitt’s disease in Africa and is highly suspicious of the existence of some Epstein-Barr-Proof pathogen. Second, the discovery of adult T-cell leukemia virus (ATLV) In 1979, Miyoshi and other application of umbilical cord blood leukocytes and peripheral blood of patients with ATL mixed culture, thus establishing a cell line from ATL MT-1.1981 daily appeared, After reacting with the serum of MTL-1 and ATL patients and then reacting with fluorescein-labeled anti-human IgG, some cells produce fluorescence, which is called ATL-related antigen.