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目的:探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年肺功能的影响。方法:将34名受试者随机分为沙美特罗组(n=18)和对照组(n=16),自海拔1 400m历时5天进入5 200m,从进入海拔5 200m当天开始,沙美特罗组每天早晚各1次吸入沙美特罗替卡松粉1个剂量(沙美特罗100μg,丙酸氟替卡松200μg),连续5天;对照组用同样的方法吸入少量生理盐水。于吸入沙美特罗替卡松粉吸入剂第5天检测两组受试者的肺功能,检测指标包括FVC、FEV1、FEV1%、MMEF、PEF和MVV。结果:沙美特罗组较对照组肺功能指标中,FVC[(3.84±0.66)L vs(3.32±0.54)L],FEV1[(3.78±0.62)Lvs(3.25±0.58)L],MMEF[(6.36±1.80)L/s vs(5.11±1.23)L/s],PEF[(8.99±2.04)L/s vs(7.54±1.88)L/s],MVV[(142.30±17.73)L vs(124.34±21.34)L]显著增高(P<0.05);FEV1%[(97.86±6.06)Lvs(95.82±7.53)L]无显著性变化(P>0.05)。结论:在高原吸入沙美特罗替卡松粉吸入剂能提高移居者的肺通气功能。
Objective: To investigate the effect of salmeterol and fluticasone powder inhalation on young lung function of young people entering high altitude area. METHODS: Thirty-four subjects were randomized to salmeterol (n = 18) and control (n = 16), and were enrolled in a range of 5 200 m from an altitude of 1 400 m for 5 days. From the day of entering an altitude of 5 200 m, In the Luo group, one dose of salmeterol and 1 mg of salmeterol and 1 mg of salmeterol and 1 μg of fluticasone propionate was inhaled daily for 5 consecutive days. The control group received a small amount of saline by the same method. Pulmonary function was measured on day 5 of inhalation of salmeterol and fluticasone powder inhalers. The indices of detection included FVC, FEV1, FEV1%, MMEF, PEF, and MVV. Results: Compared with the control group, the lung function of the salmeterol group was significantly lower than that of the control group (FVC [(3.84 ± 0.66) L vs. (3.32 ± 0.54) L], FEV1 [(3.78 ± 0.62) vs 3.25 ± 0.58 6.36 ± 1.80 L vs s P 5.11 ± 1.23 L / s PEF 8.99 ± 2.04 L vs s 7.54 ± 1.88 L vs s 142.30 ± 17.73 L vs 124.34 ± 21.34) L] (P <0.05). There was no significant change in FEV1% (97.86 ± 6.06) Lvs (95.82 ± 7.53) L (P> 0.05). CONCLUSIONS: Inhalation of salmeterol and fluticasone-based inhalers at high altitude increased lung ventilation in settlers.