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目的探讨硝普钠与酚妥拉明治疗急诊冠状动脉粥样硬化性心脏病(CHD)合并心力衰竭患者的临床效果。方法选取2016年1—12月于沈阳急救中心治疗的CHD合并心力衰竭患者92例,按照1:1比例随机将其分为硝普钠组与酚妥拉明组,每组46例,比较两组患者治疗效果。结果硝普钠组患者治疗的总有效率为82.6%,明显高于酚妥拉明组的60.9%,差异有统计学意义(P<0.05);治疗后,硝普钠组患者左心射血分数明显高于酚妥拉明组,而左心室舒张末内径、左心室收缩末内径均明显低于酚妥拉明组,差异均有统计学意义(均P<0.05);硝普钠组患者心功能指标恢复正常时间为(6.0±1.4)d,明显短于酚妥拉明组的(8±4)d,差异有统计学意义(t=3.894,P=0.000)。结论在急诊治疗CHD合并心力衰竭患者中,采用硝普钠治疗的临床效果优于酚妥拉明,可有效改善患者心功能。
Objective To investigate the clinical effects of sodium nitroprusside and phentolamine in the treatment of patients with coronary heart disease (CHD) complicated with heart failure. Methods Ninety-two CHD patients with heart failure who were treated in Shenyang Emergency Center from January to December in 2016 were randomly divided into three groups according to the ratio of 1: 1: sodium nitroprusside group and phentolamine group, with 46 cases in each group Group patients treatment effect. Results The total effective rate of patients treated with sodium nitroprusside group was 82.6%, which was significantly higher than that of the phentolamine group (60.9%, P <0.05). After treatment, left ventricular ejection fraction The score was significantly higher than the phentolamine group, while the left ventricular end-diastolic diameter, left ventricular end-systolic diameter were significantly lower than the phentolamine group, the difference was statistically significant (all P <0.05); sodium nitroprusside patients The cardiac function returned to normal (6.0 ± 1.4) d, which was significantly shorter than that of the phentolamine group (8 ± 4) d (t = 3.894, P = 0.000). Conclusion The clinical efficacy of sodium nitroprusside in the treatment of patients with CHD complicated with heart failure in emergency treatment is better than that of phentolamine, which can effectively improve the cardiac function.