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目的 :研究p5 3蛋白在非小细胞肺癌 (NSCLC)组织中的表达水平与放疗敏感性的关系。方法 :采用常规的 10 %甲醛固定 ,石蜡包埋标本 ,免疫组化分析p5 3蛋白的表达及其与放疗敏感性的关系。结果 :p5 3蛋白表达阳性率为 4 0 % (2 0 / 5 0 ) ,70 % (2 1/ 30 )的p5 3蛋白 (- )肿瘤放疗有效 ,而p5 3蛋白(+ )中仅 15 % (3/ 2 0 )有效 (P <0 .0 1)。结论 :p5 3蛋白可作为NSCLC放疗敏感性预测的参考指标。
Objective: To study the relationship between p53 protein expression and radiosensitivity in non-small cell lung cancer (NSCLC). METHODS: The expression of p53 protein and its relationship with radiosensitivity were analyzed by immunohistochemistry using a normal 10% formalin-fixed and paraffin-embedded specimen. RESULTS: The positive rate of p53 protein expression was 40% (20/50), 70% (2 1/30) of p53 protein (-) tumor radiotherapy was effective, and only 15 % of p53 protein (+) was positive. (3 / 2 0) is valid (P <0. 0 1). Conclusion : p53 protein can be used as a reference index for the prediction of radiosensitivity of NSCLC.