蓝氏贾第鞭毛虫(简称贾第虫)是一种常见的人兽共患寄生性原虫,由其导致的贾第虫病已被世界卫生组织列为危害人类健康的10种主要寄生虫病之一。近年来,贾第虫病的危害日益受到重视,然而贾第虫导致腹泻的致病机制尚不明确,可能与其细胞骨架蛋白、虫体分泌物、L-精氨酸代谢以及表面抗原变异、免疫学改变等多种因素有关,该文对与贾第虫致病机理相关的研究作一综述。 Giardia lamblia (referred to as Giardia) is a common zoonotic parasitic protozoan, the giardiasis caused by it has been the World Health Organization listed as 10 kinds of major parasitic diseases endanger human health one. In recent years, the harm of giardiasis has been paid more and more attention. However, the pathogenesis of diarrhea caused by giardiasis is not clear, which may be related to its cytoskeletal proteins, parasites secretions, L-arginine metabolism and surface antigen variation The change of biology and other factors, this article reviews the research related to the pathogenic mechanism of Giardia.