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目的探讨高砷暴露致皮肤损伤人群尿砷代谢的特点。方法应用氢化物发生-冷阱捕获-原子吸收分光光度法测定高砷暴露地区(水砷浓度分别为0.21、0.24、0.36mg/L)皮肤损伤组人群(77人)和未见皮肤损伤对照组人群(77人,性别、年龄1∶1配比)尿中无机砷(iAs)、一甲基胂酸(MMA)和二甲基胂酸(DMA)含量。以iAs、MMA及DMA的总和表示总砷(tAs)水平;以iAs/tAs、MMA/tAs和DMA/tAs分别计算iAs%、MMA%、DMA%;以(MMA+DMA)/tAs及DMA/(MMA+DMA)分别计算一甲基化率(FMR)和二甲基化率(SMR)水平。结果皮肤损伤组人群与对照组人群相比尿中各形态砷化合物及总砷含量差异无统计学意义(P>0.05),而皮肤损伤组尿iAs%水平高于对照组,DMA%、FMR和SMR水平低于对照组差异均有统计学意义(P<0.05)。皮肤损伤组人群中男性SMR水平显著低于女性,且尿中MMA%显著高于女性(P<0.05)。结论高砷暴露情况下,出现皮肤损伤症状的人群对砷的甲基化能力较低。
Objective To investigate the characteristics of urinary arsenic metabolism in skin injury patients exposed to high levels of arsenic. Methods Hydride generation-cold trap capture-atomic absorption spectrophotometry was used to detect the skin damage in high arsenic exposed area (0.21,0.24,0.36mg / L) In the population (77, sex, age 1: 1 ratio) urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) content. The total arsenic (tAs) levels were expressed as the sum of iAs, MMA and DMA; iAs%, MMA% and DMA% were calculated as iAs / tAs, MMA / tAs and DMA / tAs; (MMA + DMA) were calculated monomethylation rate (FMR) and two methylation rate (SMR) levels. Results Compared with the control group, there was no significant difference in the contents of arsenic and total arsenic in the urine of the skin lesion group and the control group (P> 0.05), while the urine iAs% of the skin lesion group was higher than that of the control group, DMA%, FMR and SMR levels were lower than the control group were statistically significant (P <0.05). The level of SMR in the skin injury group was significantly lower than that in the female group, and the MMA% in the urine group was significantly higher than that in the female group (P <0.05). Conclusions Under high arsenic exposure, people with signs of skin damage have a lower ability to methylate arsenic.