采用环状亚磷酸酯与亚胺的加成反应,合成了9个未见文献报道的含吡啶基的α-氨基环状膦酸酯化合物.其结构经1H NMR,31P NMR,MS和元素分析确证,同时采用X射线单晶衍射对化合物3i的立体构型进行了进一步确证.测定了该系列化合物的杀虫、杀菌和除草活性,结果表明,化合物的杀虫活性虽然较差,但所有化合物在药液质量浓度为1.0×10-4g/mL时都具有较好的除草活性,部分化合物在5.0×10-5g/mL时显示出良好的杀菌活性. Nine novel pyridine-based α-amino cyclic phosphonate compounds were synthesized by the addition reaction of cyclic phosphite with imine. The structures were confirmed by 1H NMR, 31P NMR, MS and elemental analysis The compound 3i was confirmed by X-ray single crystal diffraction, and the insecticidal, bactericidal and herbicidal activities of the compound were also determined.The results showed that although the insecticidal activity of the compound was poor, all the compounds The herbicidal activity was good when the mass concentration was 1.0 × 10-4g / mL. Some compounds showed good bactericidal activity at 5.0 × 10-5g / mL.