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以右旋肌醇甲醚为原料,经缩酮化、磺酸酯化、酸解脱保护、缩合等反应合成了4-[2-(1-哌嗪基)-4-氨基-6,7-二甲氧基喹唑啉基]-3-甲氧基-D-肌醇,此方法具有条件温和、便于操作和产率高等特点。利用波谱分析和元素分析对中间体和标题化合物进行了结构确定。
The synthesis of 4- [2- (1-piperazinyl) -4-amino-6,7-d] pyrimidine was synthesized from dextromethorphan ether by ketalization, sulfonation, acid deprotection and condensation. Dimethoxyquinazolinyl] -3-methoxy-D-inositol, this method has the advantages of mild conditions, convenient operation and high yield. The structures of the intermediates and the title compounds were determined using spectral analysis and elemental analysis.