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大量研究表明,一侧或大部肾切除后,残余肾组织可出现代偿性生长(CRG),表现为肾脏体积增大,重量增多,组织内RNA、DNA及蛋白质合成增加和残余肾单位功能亢进。能导致及影响CRG的因素十分庞杂,一般认为包括四个方面:神经调节,循环动力影响,超负荷工作和激素调节。特别是激素调节,目前人们越来越意识到它在肾脏代偿性生长中所起的重要作用。1958年Braun,Menendez提出一种循环物质控制着肾脏生长,并命名为促肾脏生长素(Renotropin),以后很多学者进行了一系列研究探索这种促肾因子的存在及其与CRG的关系。大量研究认为,体内存在一种促肾因子,它可能产生于垂体,不同于其它激素,具有对肾脏特异性的兴奋作用,一侧或大部分肾切
Numerous studies have shown that one or most of the nephrectomy, the residual kidney tissue may appear compensatory growth (CRG), the performance of the kidney volume increase, weight gain, tissue RNA, DNA and protein synthesis and residual nephron function Kang. The factors that can cause and influence CRG are very complex and are generally considered to include four aspects: neuromodulation, circulatory dynamics, overload and hormone regulation. Especially hormone regulation, people are more and more aware of its important role in kidney compensatory growth. In 1958, Braun, Menendez proposed that a circulating substance control the growth of the kidney and named it Renotropin. Many scholars conducted a series of studies to explore the existence of CRF and its relationship with CRG. A large number of studies suggest that the body there is a promoting factor, which may be produced in the pituitary, unlike other hormones, with kidney-specific excitatory effects, one or most of the nephrectomy