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应用免疫组化ＡＢＣ法对８４例前列腺癌（ＰＣ）、良性前列腺增生（ＢＰＨ）和非典型增生（ＰＡＨ）各３０例、以及１０例正常前列腺作了纤维连接蛋白（Ｆｉｂｒｏｎｅｃｔｉｎ，ＦＮ）标记。结果表明６３％的ＰＣ、６０％的ＰＡＨ、３７％的ＢＰＨ与３０％的正常前列腺上皮显不同的ＦＮ阳性；ＰＣ之癌间质与基膜的ＦＮ减少与缺失；ＦＮ在不同类型ＰＣ中的反应有差异，且主要见于大部分小腺泡癌、筛状癌、粘液腺癌及实体癌等；ＰＡＨ上皮的ＦＮ反应略低于ＰＣ，明显高于正常前列腺与ＢＰＨ，恶性上皮ＦＮ多呈弥漫性或散在成片的阳性着色，而良性上皮多呈局灶性ＦＮ反应。本研究证实了多数ＰＣ之癌细胞显ＦＮ强阳性或阳性反应，不同的反应强度可能与ＰＣ的类型和肿瘤细胞分化有关系；并提示癌间质与基膜ＦＮ降低和缺失可能为癌的浸润与转移提供了便利条件。
Immunohistochemical ABC method was used to detect Fibronectin (FN) in 84 cases of prostate cancer (PC), 30 cases of benign prostatic hyperplasia (BPH) and atypical hyperplasia (PAH), and 10 cases of normal prostate. The results showed that 63% of PC, 60% of PAH, 37% of BPH and 30% of normal prostate epithelium were significantly different FN positive; PC of the stroma and basement membrane of FN reduction and deletion; FN in different types of PC Reaction was different, and mainly found in most small acinar carcinoma, reticular carcinoma, mucinous adenocarcinoma and solid cancer; PAH epithelial FN response slightly lower than PC, significantly higher than normal prostate and BPH, malignant epithelial FN were diffuse Sex or scattered into a positive film coloring, and mostly benign epithelial FN reaction. This study confirmed that the majority of PC cancer cells showed FN strong positive or positive reaction, the different intensity of the reaction may be related to the type of PC and tumor cell differentiation; and suggest that the reduction and deletion of FN in cancer and basement membrane may be invasive of cancer With the transfer provided a convenient condition.