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目的观察双氧水阴道冲洗在宫颈癌放疗前应用的短期临床疗效。方法将该院接受根治性放疗的中晚期宫颈癌患者120例按照随机数字表法分为观察组(n=60)和对照组(n=60)。放疗前,观察组给予双氧水阴道冲洗,对照组给予新洁尔灭(苯扎溴铵)液冲洗,比较2组临床治疗效果、照射剂量及不良反应发生率。结果 2组近期有效率、局部复发率、远处转移率比较差异均无统计学意义(P>0.05);观察组宫颈局部肿瘤缩小50%和肿瘤缩小100%的肿瘤放射剂量和肿瘤消退时间均低于/短于对照组,差异均有统计学意义(P<0.05)。结论在宫颈癌放射治疗前,给予患者双氧水阴道冲洗可降低肿瘤照射剂量,促进肿瘤消退,但远期疗效尚待进一步观察。
Objective To observe the short-term clinical efficacy of hydrogen peroxide vaginal irrigation before cervical cancer radiotherapy. Methods One hundred and twenty patients with advanced cervical cancer undergoing radical radiotherapy were randomly divided into observation group (n = 60) and control group (n = 60). Before radiotherapy, the observation group was treated with hydrogen peroxide vaginal irrigation, and the control group was given benzalkonium bromide solution. The clinical effects, radiation dose and incidence of adverse reactions in the two groups were compared. Results There were no significant differences in the recent efficiency, local recurrence rate and distant metastasis rate between the two groups (P> 0.05). The tumor radiotherapy dose and the tumor regression time in the observation group were both 50% reduction in cervical local tumor and 100% reduction in tumor The difference between the two groups was statistically significant (P <0.05). Conclusions In patients with cervical cancer before radiotherapy, patients given hydrogen peroxide vaginal irrigation can reduce the dose of tumor irradiation and promote tumor regression, but the long-term efficacy remains to be further observed.