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目的探讨透明隔腔缺如在发现胎儿中枢神经系统畸形中的临床价值。方法回顾性分析自2014年1月至2015年12月期间在我院行产前超声筛查的孕妇21 249例中检出的透明隔腔缺如的51例病例,并与随访结果、引产后尸检病理或标本影像学检查结果进行对比分析。结果发现透明隔腔缺如51例,相关的中枢神经系统畸形如下:(1)胼胝体发育不良22例,(2)全前脑24例,23例为无叶全前脑,1例为半叶全前脑,(3)其他:视隔发育不良2例,脑穿通畸形1例,脑裂畸形1例,颅内感染1例。结论透明隔腔缺如是发现胎儿中枢神经系统畸形的重要线索之一,具有重要的临床价值。
Objective To investigate the clinical value of the transparent compartment in detecting fetal central nervous system deformity. Methods A retrospective analysis of 51 cases of missing septum in 21 249 pregnant women who were prenatal ultrasound screening in our hospital from January 2014 to December 2015 was retrospectively analyzed. Autopsy pathology or specimen imaging results for comparative analysis. The results showed that the absence of clear septum in 51 cases, related to the central nervous system deformities are as follows: (1) corpus callosum dysplasia in 22 cases, (2) 24 cases of anterior forebrain, 23 cases of non-leaf forebrain, 1 case of half All forebrain, (3) others: depending on the occurrence of dysplasia in 2 cases, 1 case of penetrating brain deformity, schizencephaly in 1 case, 1 case of intracranial infection. Conclusions The lack of clear septum is one of the important clues to discover fetal central nervous system deformity and has important clinical value.