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目的：观察糖尿病视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）患者红细胞免疫功能的变化及枸杞的治疗作用。方法：对４４例糖尿病视网膜病变患者用枸杞治疗３个月，并对治疗前后患者的红细胞Ｃ３ｂ受体花环率（ｒｅｄｂｌｏｏｄｃｅｌＣ３ｂｒｅｃｅｐｔｏｒｒｏｓｅｔｅ，ＲＢＣ－Ｃ３ｂＲＲ）、红细胞免疫复合物花环率（ＲＢＣｉｍｍｕｎｅｃｏｍｐｌｅｘｒｏｓｅｔｅ，ＲＢＣ－ＩＣＲ）及其调节因子活性进行了检查，同时与空腹血糖（ｆａｓｔｉｎｇｂｌｏｏｄｇｌｕｃｏｓｅ，ＦＢＧ）、糖基化血红蛋白（ｈｅｍｏｇｌｏｂｉｎｇｌｙｃｏｓｙｌａｔｉｏｎ，ＨｂＡ１ｃ）及血脂进行了分析。结果：糖尿病视网膜病变患者ＲＢＣ－Ｃ３ｂＲＲ明显降低（Ｐ＜０．０１），免疫粘附促进率降低，免疫粘附抑制率显著增高（Ｐ＜０．０１），而ＲＢＣ－ＩＣＲ则无明显改变（Ｐ＞０．０５）。ＲＢＣ－Ｃ３ｂＲＲ降低与免疫粘附抑制率、ＦＢＧ、ＨｂＡ１ｃ、血脂呈负相关。经枸杞治疗３个月后ＲＢＣ－Ｃ３ｂＲＲ和ＲＢＣ免疫粘附促进率升高，而ＲＢＣ免疫粘附抑制率则显著下降。结论：糖尿病视网膜病变患者为原发性红细胞免疫功能低下，枸杞对提高糖尿病视网膜病变患者的红细胞免疫功能有一定效果?
Objective: To observe the changes of erythrocyte immune function in patients with diabetic retinopathy (DR) and the therapeutic effect of Chinese wolfberry. Methods: Forty-four patients with diabetic retinopathy were treated with Chinese wolfberry for 3 months. The levels of red blood cell C3b receptor RBC-C3bRR, RBC-ICRR-RBC-ICR, The activity of regulatory factors was examined. Meanwhile, fasting blood glucose (FBG), hemoglobinglycosylation (HbA1c) and serum lipids were analyzed. Results: The RBC-C3bRR was significantly lower in patients with diabetic retinopathy (P <0.01), the rate of immune adhesion was decreased, the inhibition rate of immune adhesion was significantly increased (P <0.01), while the RBC-ICR was not significantly changed P> 0.05). The decrease of RBC-C3bRR was negatively correlated with the rate of inhibition of immune adhesion, FBG, HbA1c and blood lipids. RBC-C3bRR and RBC immunoadsorption rate increased 3 months after wolfberry treatment, while RBC immune adherence inhibition rate decreased significantly. CONCLUSIONS: Diabetic retinopathy patients with primary erythrocyte immune dysfunction, medlar to improve diabetic retinopathy in patients with erythrocyte immune function have some effect?