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目的:探讨T-型钙通道Cav3.1、Cav3.2蛋白在宫颈癌中的表达及其与宫颈癌在临床、病理及预后的关系。方法:应用免疫组化技术,检测60例正常宫颈组织和90例宫颈癌中T-型钙通道Cav3.1、Cav3.2蛋白的表达水平。结果:宫颈癌中T-型钙通道Cav3.1、Cav3.2蛋白的表达水平高于正常宫颈组织(P<0.01)。T-型钙通道Cav3.1、Cav3.2在宫颈癌组织中过表达率与临床期别、病理分化程度呈正相关(P<0.01),淋巴结转移组T-型钙通道Cav3.1、Cav3.2蛋白的过表达率高于淋巴结无转移组(P<0.05),未发现T-型钙通道Cav3.1、Cav3.2蛋白的表达与病理类型、年龄及肿瘤大小有关(P>0.05)。结论:T-型钙通道Cav3.1、Cav3.2蛋白的异常表达与宫颈癌显著相关,在宫颈癌的发生、发展和侵袭转移过程中起到促进作用,其激活可能与宫颈癌的恶性进展及预后有关。
Objective: To investigate the expression of T-type calcium channel Cav3.1 and Cav3.2 protein in cervical cancer and their relationship with clinicopathology, pathology and prognosis. Methods: The expression of T-type calcium channel Cav3.1 and Cav3.2 protein in 60 cases of normal cervical tissue and 90 cases of cervical cancer were detected by immunohistochemistry. Results: The expressions of Cav3.1 and Cav3.2 in T-type calcium channel in cervical cancer were higher than those in normal cervical tissue (P <0.01). The overexpression rates of T-type calcium channel Cav3.1 and Cav3.2 in cervical cancer tissues were positively correlated with the clinical stage and the degree of pathological differentiation (P <0.01), and the expression of T-type calcium channel Cav3.1 and Cav3 in lymph node metastasis group. The overexpression rate of Cav3.2 and Cav3.2 protein in T-type calcium channel was not correlated with pathological type, age and tumor size (P> 0.05). CONCLUSION: Abnormal expression of T-type calcium channel Cav3.1 and Cav3.2 protein is significantly associated with cervical cancer and plays an important role in carcinogenesis, development and invasion and metastasis of cervical cancer, which may be related to the malignant progression of cervical cancer And the prognosis.